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Вопросы гематологии/онкологии и иммунопатологии в педиатрии

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Современные представления о патогенезе гемофилической артропатии

https://doi.org/10.24287/1726-1708-2015-14-3-5-12

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Аннотация

Основным проявлением гемофилии являются кровоизлияния в крупные суставы. Гемартроз запускает патогенети- ческий каскад, который может привести к развитию гемофилической артропатии. Кровь оказывает негативное влия- ние на состояние хрящевой ткани и синовиальной оболочки сустава. В ходе многочисленных исследований была показана ключевая роль профилактической гемостатической терапии в предотвращении развития гемофилической артропатии. Знание фармакокинетических характеристик препарата позволяет корректировать дозы вводимого кон- центрата фактора свертывания крови и избегать длительного снижения активности дефицитного фактора в крови менее 1%, что дает возможность предотвратить возникновение спонтанных кровотечений и развитие артропатии.

Об авторах

Т. Ю. Полянская
Гематологический научный центр Минздрава России
Россия


В. Ю. Зоренко
Гематологический научный центр Минздрава России
Россия


Е. Е. Карпов
Гематологический научный центр Минздрава России
Россия


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Для цитирования:


Полянская Т.Ю., Зоренко В.Ю., Карпов Е.Е. Современные представления о патогенезе гемофилической артропатии. Вопросы гематологии/онкологии и иммунопатологии в педиатрии. 2015;14(3):5-12. https://doi.org/10.24287/1726-1708-2015-14-3-5-12

For citation:


Polyanskaya T.Y., Zorenko V.Y., Karpov E.E. Modern concepts of the pathogenesis of haemophilic arthropathy. Pediatric Hematology/Oncology and Immunopathology. 2015;14(3):5-12. (In Russ.) https://doi.org/10.24287/1726-1708-2015-14-3-5-12

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ISSN 1726-1708 (Print)
ISSN 2414-9314 (Online)