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Вопросы гематологии/онкологии и иммунопатологии в педиатрии

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Тромбозы у детей с острым лимфобластным лейкозом

https://doi.org/10.24287/1726-1708-2015-14-3-39-47

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Аннотация

Успехи современной науки привели к тому, что бессобытийная выживаемость детей с острым лимфобластным лейко- зом (ОЛЛ) составляет более 80%. Летальные случаи заболевания в настоящее время чаще всего связаны с осложне- ниями терапии. Соответственно, дальнейшее улучшение результатов лечения ОЛЛ у детей может быть обеспечено, прежде всего, за счет эффективных методов профилактики и лечения осложнений, а также за счет снижения токсич- ности применяемых программ терапии. Одним из опасных осложнений терапии ОЛЛ, оказывающих неблагоприятное влияние на результаты лечения и, как следствие, на выживаемость пациентов, является тромбоз - прижизненное образование сгустков крови в просвете сосудов или в полостях сердца. В статье, представляющей собой обзор лите- ратуры, представлены данные о частоте, патогенезе, факторах риска, диагностике, возможностях современной тера- пии и профилактики этого грозного осложнения.

Об авторах

Л. И. Жарикова
Федеральный научно-клинический центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева Минздрава России; Российский национальный исследовательский медицинский университет им. Н.И.Пирогова Минздрава России
Россия


Ю. В. Румянцева
Федеральный научно-клинический центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева Минздрава России; Российский национальный исследовательский медицинский университет им. Н.И.Пирогова Минздрава России
Россия


А. И. Карачунский
Федеральный научно-клинический центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева Минздрава России; Российский национальный исследовательский медицинский университет им. Н.И.Пирогова Минздрава России
Россия


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Для цитирования:


Жарикова Л.И., Румянцева Ю.В., Карачунский А.И. Тромбозы у детей с острым лимфобластным лейкозом. Вопросы гематологии/онкологии и иммунопатологии в педиатрии. 2015;14(3):39-47. https://doi.org/10.24287/1726-1708-2015-14-3-39-47

For citation:


Zharikova L.I., Rumyantseva Y.V., Karachunsky A.I. Thromboses in children with acute lymphoblastic leukemia. Pediatric Hematology/Oncology and Immunopathology. 2015;14(3):39-47. (In Russ.) https://doi.org/10.24287/1726-1708-2015-14-3-39-47

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