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Вопросы гематологии/онкологии и иммунопатологии в педиатрии

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Перспективы практического применения молекулярно-генетической стратификации групп риска у детей с медуллобластомой

https://doi.org/10.24287/1726-1708-2016-15-4-74-80

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Аннотация

Генетические исследования последних 10 лет привели к драматическим изменениям в представлении о биологии медуллобластом. Выделены 4 молекулярно-генетические группы медуллобластом: WNT (Wingless), SHH (SonicHedgehog), группа 3, группа 4, значимо различающиеся по спектру экспрессируемых генов, клиническому течению и прогнозу. Адекватное лечение, в том числе использование таргетных препаратов, требует стратификации в соответствии с новыми критериями.

Об авторах

Людмила Ивановна Папуша
Федеральный научно-клинический центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева Минздрава России
Россия


Александр Георгиевич Друй
Федеральный научно-клинический центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева Минздрава России
Россия


Людмила Александровна Ясько
Федеральный научно-клинический центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева Минздрава России
Россия


Юлия Вячеславовна Ольшанская
Федеральный научно-клинический центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева Минздрава России
Россия


Элла Вячеславовна Кумирова
Федеральный научно-клинический центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева Минздрава России
Россия


Галина Анатольевна Новичкова
Федеральный научно-клинический центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева Минздрава России
Россия


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Для цитирования:


Папуша Л.И., Друй А.Г., Ясько Л.А., Ольшанская Ю.В., Кумирова Э.В., Новичкова Г.А. Перспективы практического применения молекулярно-генетической стратификации групп риска у детей с медуллобластомой. Вопросы гематологии/онкологии и иммунопатологии в педиатрии. 2016;15(4):74-80. https://doi.org/10.24287/1726-1708-2016-15-4-74-80

For citation:


Papusha L.I., Drui A.G., Yas'ko L.A., Ol'shanskaya Y.V., Kumirova E.V., Novichkova G.A. Perspectives of the practical use of molecular-genetic stratification of risk groups among children with medulloblastoma. Pediatric Hematology/Oncology and Immunopathology. 2016;15(4):74-80. (In Russ.) https://doi.org/10.24287/1726-1708-2016-15-4-74-80

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ISSN 1726-1708 (Print)
ISSN 2414-9314 (Online)