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Новое в патогенезе, диагностике и лечении хронической реакции «трансплантат против хозяина» после аллогенной ТГСК

https://doi.org/10.24287/1726-1708-2018-17-2-121-135

Аннотация

Хроническая реакция «трансплантат против хозяина» (РТПХ) остается ведущим осложнением аллогенной трансплантации гемопоэтических стволовых клеток (ТГСК), определяющим поражение множества органов и систем, и характеризуется комбинацией ауто- и аллоиммунной дисрегуляции, формированием иммунного дефицита и нарушением качества жизни. Частота возникновения хронической РТПХ при аллогенных ТГСК составляет 30-70% у взрослых и 15-40% у детей. Сложности в диагностике и лечении хронической РТПХ связаны с проблемами унификации оценки поражения и степени ее тяжести. В данном обзоре описаны современные воззрения на патогенез, международные критерии диагностики, представлены новые подходы к терапии данного осложнения.

Об авторах

Ю.В. Скворцова
ФГБУ «Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева» Минздрава России
Россия


Г.А. Новичкова
ФГБУ «Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева» Минздрава России
Россия


А.А. Масчан
ФГБУ «Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева» Минздрава России
Россия


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Рецензия

Для цитирования:


Скворцова Ю., Новичкова Г., Масчан А. Новое в патогенезе, диагностике и лечении хронической реакции «трансплантат против хозяина» после аллогенной ТГСК. Вопросы гематологии/онкологии и иммунопатологии в педиатрии. 2018;17(2):121-135. https://doi.org/10.24287/1726-1708-2018-17-2-121-135

For citation:


Skvortsova Y.V., Novichkova G.A., Maschan A.A. New advances in pathogenesis, diagnostic and treatment of chronic graft-versus-host disease after allogeneic hematopoietic stem cell transplantation. Pediatric Hematology/Oncology and Immunopathology. 2018;17(2):121-135. (In Russ.) https://doi.org/10.24287/1726-1708-2018-17-2-121-135

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