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Эволюция метода тотального облучения тела: от истории к современности

https://doi.org/10.24287/1726-1708-2018-17-3-133-139

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Аннотация

В обзоре представлена информация о тотальном облучении тела (ТОТ): история становления метода, краткое описание классических методик подведения дозы и основные сложности их использования. В последние годы все чаще применяют ТОТ с использованием лучевой терапии с модуляцией интенсивности (Intensity Modulated Radiation Therapy – IMRT). Это предполагает снижение токсичности терапии без увеличения вероятности возникновения рецидивов. Использование IMRT позволяет унифицировать распределение дозы внутри пациентов, а также, что особенно важно, использовать четкие количественные критерии, необходимые для сравнения клинической эффективности и токсичности различных режимов терапии. В статье обсуждаются некоторые радиобиологические аспекты ТОТ, касающиеся используемой при облучении мощности дозы, облучения кожи и равномерности облучения циркулирующей крови.

Об авторах

А. А. Логинова
ФГБУ «Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева»
Россия

Логинова Анна Анзоровна, старший медицинский физик, отделение лучевой терапии 

117997, Москва, ГСП-7, ул. Саморы Машела, 1 



А. А. Нечеснюк
ФГБУ «Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева»
Россия


Д. А. Кобызева
ФГБУ «Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева»
Россия


А. П. Черняев
ФГБОУ ВО «Московский государственный университет им. М.В. Ломоносова»
Россия


С. М. Варзарь
ФГБОУ ВО «Московский государственный университет им. М.В. Ломоносова»
Россия


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Для цитирования:


Логинова А.А., Нечеснюк А.А., Кобызева Д.А., Черняев А.П., Варзарь С.М. Эволюция метода тотального облучения тела: от истории к современности. Вопросы гематологии/онкологии и иммунопатологии в педиатрии. 2018;17(3):133-139. https://doi.org/10.24287/1726-1708-2018-17-3-133-139

For citation:


Loginova A.A., Nechesnyuk A.A., Kobyzeva D.A., Chernyaev A.P., Varzar S.M. Development of total body irradiation method. From history to the present. Pediatric Hematology/Oncology and Immunopathology. 2018;17(3):133-139. (In Russ.) https://doi.org/10.24287/1726-1708-2018-17-3-133-139

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ISSN 1726-1708 (Print)
ISSN 2414-9314 (Online)