Эволюция метода тотального облучения тела: от истории к современности

В обзоре представлена информация о тотальном облучении тела (ТОТ): история становления метода, краткое описание классических методик подведения дозы и основные сложности их использования. В последние годы все чаще применяют ТОТ с использованием лучевой терапии с модуляцией интенсивности (Intensity Modulated Radiation Therapy – IMRT). Это предполагает снижение токсичности терапии без увеличения вероятности возникновения рецидивов. Использование IMRT позволяет унифицировать распределение дозы внутри пациентов, а также, что особенно важно, использовать четкие количественные критерии, необходимые для сравнения клинической эффективности и токсичности различных режимов терапии. В статье обсуждаются некоторые радиобиологические аспекты ТОТ, касающиеся используемой при облучении мощности дозы, облучения кожи и равномерности облучения циркулирующей крови.

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