Эволюция метода тотального облучения тела: от истории к современности
https://doi.org/10.24287/1726-1708-2018-17-3-133-139
Аннотация
В обзоре представлена информация о тотальном облучении тела (ТОТ): история становления метода, краткое описание классических методик подведения дозы и основные сложности их использования. В последние годы все чаще применяют ТОТ с использованием лучевой терапии с модуляцией интенсивности (Intensity Modulated Radiation Therapy – IMRT). Это предполагает снижение токсичности терапии без увеличения вероятности возникновения рецидивов. Использование IMRT позволяет унифицировать распределение дозы внутри пациентов, а также, что особенно важно, использовать четкие количественные критерии, необходимые для сравнения клинической эффективности и токсичности различных режимов терапии. В статье обсуждаются некоторые радиобиологические аспекты ТОТ, касающиеся используемой при облучении мощности дозы, облучения кожи и равномерности облучения циркулирующей крови.
Об авторах
А. А. ЛогиноваРоссия
Логинова Анна Анзоровна, старший медицинский физик, отделение лучевой терапии
117997, Москва, ГСП-7, ул. Саморы Машела, 1
А. А. Нечеснюк
Россия
Д. А. Кобызева
Россия
А. П. Черняев
Россия
С. М. Варзарь
Россия
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Рецензия
Для цитирования:
Логинова А.А., Нечеснюк А.А., Кобызева Д.А., Черняев А.П., Варзарь С.М. Эволюция метода тотального облучения тела: от истории к современности. Вопросы гематологии/онкологии и иммунопатологии в педиатрии. 2018;17(3):133-139. https://doi.org/10.24287/1726-1708-2018-17-3-133-139
For citation:
Loginova A.A., Nechesnyuk A.A., Kobyzeva D.A., Chernyaev A.P., Varzar S.M. Development of total body irradiation method. From history to the present. Pediatric Hematology/Oncology and Immunopathology. 2018;17(3):133-139. (In Russ.) https://doi.org/10.24287/1726-1708-2018-17-3-133-139