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Вопросы гематологии/онкологии и иммунопатологии в педиатрии

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Циторедуктивные операции и внутрибрюшная гипертермическая химиоперфузия у детей. Обзор литературы

Аннотация

Циторедуктивное оперативное вмешательство с проведением внутрибрюшной гипертермической химиотерапии (hyperthermic intraperitoneal chemotherapy (HIPEC)) является операцией выбора  у определенных групп пациентов взрослого возраста. Циторедукцию и HIPEC выполняют взрослым пациентам с раком яичников, желудка, колоректальным раком, карциноме червеобразного отростка, мезотелиоме брюшины и при ряде опухолей других локализаций. В педиатрической популяции опыт применения циторедукции и HIPEC ограничен, так как у детей реже встречается распространение злокачественных опухолей по брюшине. В то же время, до 30% всех злокачественных новообразований у детей развиваются в брюшной полости и полости малого таза, для которых характерна высокая частота рецидивов, особенно при повреждении целостности опухоли. Учитывая невысокую встречаемость эпителиальных  карцином у детей, HIPEC находит большее применение у пациентов с другими типами злокачественных опухолей, таких как десмопластическая мелкокруглоклеточная опухолью (ДМКО), герминогенно-клеточные опухоли, рабдомиосаркомы и другие. Целью данной работы является анализ мирового опыта применения циторедукции и HIPEC в педиатрической практике.

Об авторах

Дмитрий Гурамович Ахаладзе
НМИЦ ДГОИ им. Дмитрия Рогачева
Россия


Гавриил Савельвич Рабаев
НМИЦ ДГОИ им. Дмитрия Рогачева


Николай Сергеевич Грачев
НМИЦ ДГОИ им. Дмитрия Рогачева


Гавриил Савельвич Рабаев
НМИЦ ДГОИ им. Дмитрия Рогачева


Николай Сергеевич Грачев
НМИЦ ДГОИ им. Дмитрия Рогачева


Гавриил Савельвич Рабаев
НМИЦ ДГОИ им. Дмитрия Рогачева


Гавриил Савельвич Рабаев
НМИЦ ДГОИ им. Дмитрия Рогачева


Гавриил Савельвич Рабаев
НМИЦ ДГОИ им. Дмитрия Рогачева


Николай Сергеевич Грачев
НМИЦ ДГОИ им. Дмитрия Рогачева


Гавриил Савельвич Рабаев
НМИЦ ДГОИ им. Дмитрия Рогачева


Николай Сергеевич Грачев
НМИЦ ДГОИ им. Дмитрия Рогачева


Николай Сергеевич Грачев
НМИЦ ДГОИ им. Дмитрия Рогачева


Николай Сергеевич Грачев
НМИЦ ДГОИ им. Дмитрия Рогачева


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Ахаладзе Д.Г., Рабаев Г.С., Грачев Н.С., Рабаев Г.С., Грачев Н.С., Рабаев Г.С., Рабаев Г.С., Рабаев Г.С., Грачев Н.С., Рабаев Г.С., Грачев Н.С., Грачев Н.С., Грачев Н.С. Циторедуктивные операции и внутрибрюшная гипертермическая химиоперфузия у детей. Обзор литературы. Вопросы гематологии/онкологии и иммунопатологии в педиатрии. 2019;18(4).

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