Циторедуктивные операции и внутрибрюшная гипертермическая химиоперфузия у детей. Обзор литературы

Циторедуктивное оперативное вмешательство с проведением внутрибрюшной гипертермической химиотерапии (hyperthermic intraperitoneal chemotherapy (HIPEC)) является операцией выбора  у определенных групп пациентов взрослого возраста. Циторедукцию и HIPEC выполняют взрослым пациентам с раком яичников, желудка, колоректальным раком, карциноме червеобразного отростка, мезотелиоме брюшины и при ряде опухолей других локализаций. В педиатрической популяции опыт применения циторедукции и HIPEC ограничен, так как у детей реже встречается распространение злокачественных опухолей по брюшине. В то же время, до 30% всех злокачественных новообразований у детей развиваются в брюшной полости и полости малого таза, для которых характерна высокая частота рецидивов, особенно при повреждении целостности опухоли. Учитывая невысокую встречаемость эпителиальных  карцином у детей, HIPEC находит большее применение у пациентов с другими типами злокачественных опухолей, таких как десмопластическая мелкокруглоклеточная опухолью (ДМКО), герминогенно-клеточные опухоли, рабдомиосаркомы и другие. Целью данной работы является анализ мирового опыта применения циторедукции и HIPEC в педиатрической практике.

1. Thomassen I, van Gestel YR, Lemmens VE. Incidence, prognosis, and treatment options for patients with synchronous peritoneal carcinomatosis and liver metastases from colorectal origin. Dis Colon Rectum. 2013;56(12):1373–80. doi.org/10.1097/DCR.0b013e3182a62d9d

2. Meigs JV. Tumors of the female pelvic organs. New York: Macmillan; 1934.

3. Sugarbaker PH. Peritonectomy procedures. Ann Sur1995;221:29–42.

4. Gilly FN, Beaujard A, Glehen O, Caillot JL, Francois Y, Sadeghi-Looyeh B, et al. Peritonectomy combined with intraperitoneal chemohyperthermia in abdominal cancer with peritoneal carcinomatosis: phase I-II study. Anticancer Res. 1999;19:2317–21

5. Glehen O, Cotte E, Kusamura S, Deraco M, Baratti D, Passot G, et al. Hyperthermic intraperitoneal chemotherapy: nomenclature and modalities of perfusion. J Surg Oncol. 2008;98:242–6 doi: 10.1002/jso.21061

6. Elias D, Antoun S, Goharin A, Otmany AE, Puizillout JM, Lasser P. Research on the best chemohyperthermia technique of treatment of peritoneal carcinomatosis after complete resection. Int J Surg Investig. 2000;1:431–9

7. Ceelen W, Flessner M. Intraperitoneal therapy for peritoneal tumors: biophysics and clinical evidence. Nat Rev Clin Oncol. 2009;2010(7):108–15. doi.org/10.1038/nrclinonc.2009.217

8. Brucher BL, Piso P, Verwaal V, Esquivel J, Derraco M, Yonemura Y. Peritoneal carcinomatosis: cytoreductive surgery and HIPEC—overview fnd basics. Cancer Investig. 2012;30:209–24 doi: 10.3109/07357907.2012.654871

9. Hildebrandt B, Wust P, Ahlers O, Sreenivasa G, Kerner T, Felix R, et al. The cellular and molecular basis of hyperthermia. Crit Rev Oncol Hematol. 2002;43:33–56

10. Coccolini F, Gheza F, Lotti M, Virzì S, Iusco D, Ghermandi C, et al. Peritoneal carcinomatosis. World J Gastroenterol. 2013;19(41):6979-94. doi: 10.3748/wjg.v19.i41.6979

11. Glehen O, Mithieux F, Osinsky D, Beaujard AC, Freyer G, Guertsch P, et al. Surgery combined with peritonectomy procedures and intraperitoneal chemohyperthermia in abdominal cancers with peritoneal carcinomatosis: A phase II study. J Clin Oncol 2003;21:799–806 doi: 10.1200/JCO.2003.06.139

12. Lambert LA Looking up: Recent advances in understanding and treating peritoneal carcinomatosis.CA Cancer J Clin. 2015 Jul-Aug;65(4):284-98. doi: 10.3322/caac.21277

13. De Bree E, Romanos, J, Michalakis J, Relakis K, Georgoulias V, Melissas J,Intraoperative hyperthermic intraperitoneal chemotherapy with docetaxel as second-line treatment for peritoneal carcinomatosis of gynaecological origin Anticancer Research Volume 23, Issue 3 C, May 2003, Pages 3019-3027

14. Verwaal VJ, Van Ruth S, De Bree E, van Sloothen GW, van Tinteren H, Boot H et al. Randomized trial of cytoreduction and hyperthermic intraperitoneal chemotherapy versus systemic chemotherapy and palliative surgery in patients with peritoneal carcinomatosis of colorectal cancer. Journal of Clinical Oncology. 2003;21(20):3737-43. doi: 10.1200/JCO.2003.04.187

15. Yan TD, Welch L, Black D, Sugarbaker PH. A systematic review on the efficacy of cytoreductive surgery combined with perioperative intraperitoneal chemotherapy for diffuse malignancy peritoneal mesothelioma. Annals of Oncology. 2007;18(5):827-34. doi: 10.1093/annonc/mdl428

16. Glehen O, Passot G, Cotte E, Bakrin N. Peritoneal surface diseases. Hepato-Gastro and Oncologie Digestive. 2014;21(8):630-41. doi : 10.1684/hpg.2014.1062

17. Sommariva A, Pilati P, Rossi CR. Cyto-reductive Surgery combined with Hyperthermic Intra- peritoneal Chemotherapy for Peritoneal Surface Malignancies: current treatment and results. Cancer Treat Rev. 2012; 38(4):258-68. doi: 10.1016/j.ctrv.2011.07.001

18. Yan TD, Deraco M, Baratti D, Kusamura S, Elias D, Glehen O, et al. Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for malignant peritoneal mesothelioma: Multi- institutional experience. Journal of Clinical Oncology. 2009;27(36):6237-42. doi: 10.1200/JCO.2009.23.9640

19. Helm JH, Miura JT, Glenn JA, Marcus RK, Larrieux G, Jayakrishnan TT, et al. Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Malignant Peritoneal Mesothelioma: A Systematic Review and Meta-analysis. Annals of Surgical Oncology. 2015;22(5):1686-93. Doi: 10.1245/s10434-014-3978-x

20. Sommariva A, Pilati P, Rossi CR. Cyto-reductive Surgery combined with Hyperthermic Intra- peritoneal Chemotherapy for Peritoneal Surface Malignancies: current treatment and results. Cancer Treat Rev. 2012;38(4):258-68 doi: 10.1016/j.ctrv.2011.07.001

21. McBride K, McFadden D, Osler T. Improved survival of patients with pseudomyxoma peritonei receiving intraperitoneal chemotherapy with cytoreductive surgery: A systematic review and meta-analysis. Journal of Surgical Research. 2013;183(1):246-52 doi: 10.1016/j.jss.2012.12.040

22. Chua TC, Moran BJ, Sugarbaker PH Levine EA, Glehen O, Gilly FN, et al. Early- and long-term outcome data of patients with pseudomyxoma peritonei from appendiceal origin treated by a strategy of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. J Clin Oncol. 2012;30(20):2449-56 doi: 10.1200/JCO.2011.39.7166

23. Bryan ML, Fitzgerald NC, Levine EA, Shen P, Stewart JH, Votanopoulos KI.. Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy in sarcomatosis from gastrointestinal stromal tumor. Am Surg. 2014;80(9):890–5

24. Al-Badawi IA, Abu-Zaid A, Azzam A, Al-Omar O, AlHusaini H, Amin T.. Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for man- agement of recurrent/relapsed ovarian granulosa cell tumor: a single-center experience. J Obstet Gynaecol Res. 2014;40(9):2066–75 doi: 10.1111/jog.12460

25. Salti G, Ailabouni L, Undevia S. Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for the treatment of peritoneal sarcomatosis. Ann Surg Oncol. 2012;19(5):1410–5 doi: 10.1245/s10434-012-2240-7

26. Van Oudheusden TR, Lemmens VE, Braam HJ. Peritoneal metastases from small bowel cancer: results of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in The Netherlands. Surgery. 2015;157(6):1023–7 doi: 10.1016/j.surg.2015.01.021

27. Goéré D, Passot G, Gelli M Levine EA, Bartlett DL, Sugarbaker PH et al. On behalf the PSOGI; BIG-RENAPE Working Groups. Complete cytore- ductive surgery plus HIPEC for peritoneal metasta- ses from unusual cancer sites of origin: results from a worldwide analysis issue of the peritoneal surface oncology group international (PSOGI). Int J Hyperth. 2017;8:1–35. doi.org/10.1080/02656736.2017. 1301576

28. Honore C, Goere D, Dartgues P Burtin P, Dumont F, Elias D. Peritoneal Carcinomatosis from Solid Pseudopapillary Neoplasm (Frantz's Tumour) of the Pancreas Treated with HIPEC. Anticancer Research. 2012;32(3):1069-7

29. Cytoreductive Surgery (CRS) With/Without HIPEC in Gastric Cancer With Peritoneal Carcinomatosis (GASTRIPEC). https://clinicaltrials.gov/ct2/show/NCT02158988

30. Adjuvant Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Versus no HIPEC in Locally Advanced Colorectal Cancer (APEC Study). https://clinicaltrials.gov/ct2/show/NCT02965248

31. Huh WW, Fitzgerald NE, Mahajan A, Hayes-Jordan A. Peritoneal sarcomatosis in pediatric malignancies. Pediatr Blood Cancer. 2013;60(1):12-7 doi: 10.1002/pbc.24293

32. Hayes-Jordan A, Green H, Lin H Owusu-Agyemang P, Mejia R, Okhuysen-Cawley R, et al. Cytoreductive surgery and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) for children, adolescents, and young adults: the first 50 cases. Ann Surg Oncol. 2015;22(5):1726-32 doi: 10.1245/s10434-014-4289-y

33. Smith AW, Seibel NL, Lewis DR Albritton KH, Blair DF, Blanke CD et al. Next steps for adolescent and young adult oncology workshop: An update on progress and recommendations for the future. Cancer. 2016;122(7):988-99 doi: 10.1002/cncr.29870

34. Barr RD, Ferrari A, Ries L, Whelan J, Bleyer WA. Cancer in adolescents and young adults: A narrative review of the current status and a view of the future. JAMA Pediatrics. 2016;170(5):495-501 doi: 10.1001/jamapediatrics.2015.4689

35. Howell SB, Pfeifle CE, Olshen RA. Intraperitoneal chemotherapy with melphalan. Ann Intern Med. 1984;101(1):14-8

36. Hayes-Jordan A, Anderson P, Curley S, Herzog C, Lally KP, Green HL, et al. Continuous hyperthermic peritoneal perfusion for desmoplastic small round cell tumor. Journal of Pediatric Surgery. 2007;42(8) doi: 10.1016/j.jpedsurg.2007.05.047

37. Reingruber B, Boettcher MI, Klein P, Hohenberger W, Peltz JOW. Hyperthermic intraperitoneal chemoperfusion is an option for treatment of peritoneal carcinomatosis in children. Journal of Pediatric Surgery. 2007;42(9) doi: 10.1016/j.jpedsurg.2007.06.009

38. Hayes-Jordan, A., Green, H. L., Lin, H., Owusu-Agyemang P, Fitzgerald N, Arunkumar R et al. Complete Cytoreduction and HIPEC Improves Survival in Desmoplastic Small Round Cell Tumor. Annals of Surgical Oncology, 21(1), 220–224. doi:10.1245/s10434-013-3269-y

39. A Hayes-Jordan, CLopez, HL Green. Cytoreductive Surgery (CRS) and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in Pediatric Ovarian Tumors: A Novel Treatment Approach Pediatr Surg Int. 2016 January ; 32(1): 71–73. doi:10.1007/s00383-015-3814-9

40. Schultz, K. A. P., Sencer, S. F., Messinger, Neglia JP, Steiner ME..Pediatric ovarian tumors: A review of 67 cases. Pediatric Blood & Cancer, 44(2), 2005, 167–173.doi:10.1002/pbc.20233

41. Hayes-Jordan, A. A., Coakley, B. A., Green, H. L., Xiao L, Fournier KF, Herzog CE, et al. Desmoplastic Small Round Cell Tumor Treated with Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy: Results of a Phase 2 Trial. Annals of Surgical Oncology, 25(4), 2018, 872–877. doi:10.1245/s10434-018-6333-9

42. Subbiah, V., Lamhamedi-Cherradi, S.-E, Menegaz BA, Camacho P, Huh Wet al Multimodality Treatment of Desmoplastic Small Round Cell Tumor: Chemotherapy and Complete Cytoreductive Surgery Improve Patient Survival. Clinical Cancer Research. (2018). doi:10.1158/1078-0432.ccr-18-0202

43. Honore´ C, Atallah V, Mir O, Orbach D, Ferron G, LePéchoux C, et al. Abdominal desmoplastic small round cell tumor without extraperitoneal metastases: Is there a benefit for HIPEC after macroscopically complete cytoreductive surgery? PLoS ONE 12(2): e0171639. doi:10.1371/journal.pone.0171639

44. Bautista, F., Elias, D., Pasqualini, C., Valteau-Couanet D, Brugières L. Hyperthermic intraperitoneal chemotherapy after cytoreductive surgery for the treatment of peritoneal carcinomatosis in pediatric solid malignancies: a single institution experience. Journal of Pediatric Surgery, 49(8), 1276–1279. doi:10.1016/j.jpedsurg.2014.01.054.

45. Rodríguez Silva C, Moreno Ruiz FJ, Bellido Estévez I, Carrasco Campos J, Titos García A, Ruiz López Met al. Are there intra-operative hemodynamic differences between the Coliseum and closed HIPEC techniques in the treatment of peritoneal metastasis? A retrospective cohort study.World J Surg Oncol. 2017;15(1):51.2017 Feb 21. doi:10.1186/s12957-017-1119-2

46. Scalabre, A., Philippe-Chomette, P., Passot, G. Orbach D, Elias D, Corradini N, et al.Cytoreductive surgery and hyperthermic intraperitoneal perfusion with chemotherapy in children with peritoneal tumor spread: A French nationwide study over 14 years. Pediatric Blood & Cancer, 2018 65(4), e26934. doi:10.1002/pbc.26934

47. Dueck AC, Mendoza TR, Mitchell SA, Reeve BB, Castro KM, Rogak LJ et al. Validity and Reliability of the US National Cancer Institute's Patient-Reported Outcomes Version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE). JAMA Oncol. 2015;1(8):1051-9 doi: 10.1001/jamaoncol.2015.2639

48. Gesche, J., Beckert, S., Neunhoeffer, F., Kachanov D, Königsrainer A, Seitz G et al. Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: A safe treatment option for intraperitoneal rhabdomyosarcoma in children below 5 years of age. Pediatric Blood & Cancer, e27517. 2018 doi:10.1002/pbc.27517

49. Winer L, Macedo FI, Alfawaz A, Sommariva A, Cecchetto G, Podda A, et al. Novel Therapy for Pediatric Angiosarcoma With Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy J Pediatr Hematol Oncol. 2018 Nov;40(8):e505-e510. doi: 10.1097/MPH.0000000000001231

50. Zmora, O., Hayes-Jordan, A., Nissan, A. Kventsel I, Newmann Y, Itskovsky K et al (2018). Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) for disseminated intra-abdominal malignancies in children—a single-institution experience. Journal of Pediatric Surgery, 53(7), 1381–1386. doi:10.1016/j.jpedsurg.2017.09.014

51. Dhir M, Ramalingam L, Shuai Y, Pakrafter S, Jones HL, Hogg ME. Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemoperfusion in Adolescent and Young Adults with Peritoneal Metastases. Annals of Surgical Oncology. 2016:1-9 doi: 10.1245/s10434-016-5689-y

52. Hayes-Jordan A, Green H, Ludwig J, Anderson P. Toxicity of hyperthermic intraperitoneal chemotherapy (HIPEC) in pediatric patients with sarcomatosis/carcinomatosis: early experience and phase 1 results. Pediatr Blood Cancer. 2012;59(2):395-7 doi: 10.1002/pbc.24160

53. Womack AM, Hayes-Jordan A, Pratihar R, Barringer DA, Hall JH Jr, Gidley PW et al. Evaluation of ototoxicity in patients treated with hyperthermic intraperitoneal chemotherapy (HIPEC) with cisplatin and sodium thiosulfate. Ear Hear. 2014;35(6):e243-7 doi: 10.1097/AUD.0000000000000070

54. Ortega-Deballon P, Glehen O, Levine EP, Sugarbaker PH., Hayes-Jordan A, et al. Childbearing after hyperthermic intraperitoneal chemotherapy: results from an international survey. Ann Surg Oncol. 2011;18(8):2297-301 doi: 10.1245/s10434-011-1595-5