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Вопросы гематологии/онкологии и иммунопатологии в педиатрии

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Молекулярно-генетические характеристики глиом у детей

https://doi.org/10.24287/1726-1708-2019-18-4-109-117

Аннотация

Глиомы – самые распространенные опухоли центральной нервной системы с чрезвычайно вариабельным клиническим течением. Широкое распространение высокопроизводительных технологий в исследовательской практике позволило расширить знания о молекулярной биологии глиальных опухолей, а также определить новые патогенетические и прогностические маркеры для подбора персонализированной противоопухолевой терапии. В обзоре обсуждается роль соматических мутаций в генах BRAF, H3F3A, Hist1H3B/С, IDH1/2, транслокаций с участием генов BRAF, NTRK1/2/3 и нарушений числа копий генов CDKN2A/B в патогенезе глиом у детей, а также возможность стратификации пациентов на группы риска в соответствии с прогностической значимостью патогенных вариантов.

Об авторах

М. А. Зайцева
ФГБУ «Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева» Минздрава России
Россия

Контактная информация: Зайцева Маргарита Алексеевна, врач клинической лабораторной диагностики лаборатории молекулярной онкологии НМИЦ детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева Минздрава России.

Адрес: 117997, Москва, ГСП-7, ул. Саморы Машела, 1


Л. А. Ясько
ФГБУ «Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева» Минздрава России
Россия
Москва


Л. И. Папуша
ФГБУ «Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева» Минздрава России
Россия
Москва


А. Е. Друй
ФГБУ «Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева» Минздрава России; ГАУЗ СО «Институт медицинских клеточных технологий»
Россия
Москва


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Рецензия

Для цитирования:


Зайцева М.А., Ясько Л.А., Папуша Л.И., Друй А.Е. Молекулярно-генетические характеристики глиом у детей. Вопросы гематологии/онкологии и иммунопатологии в педиатрии. 2019;18(4):109-117. https://doi.org/10.24287/1726-1708-2019-18-4-109-117

For citation:


Zaytseva M.A., Yasko L.A., Papusha L.I., Druy A.E. Molecular genetic features of pediatric gliomas. Pediatric Hematology/Oncology and Immunopathology. 2019;18(4):109-117. (In Russ.) https://doi.org/10.24287/1726-1708-2019-18-4-109-117

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ISSN 1726-1708 (Print)
ISSN 2414-9314 (Online)