Preview

Вопросы гематологии/онкологии и иммунопатологии в педиатрии

Расширенный поиск

Циторедуктивные операции и внутрибрюшная гипертермическая химиоперфузия у детей

https://doi.org/10.24287/1726-1708-2019-18-4-118-126

Полный текст:

Аннотация

Циторедуктивное оперативное вмешательство с проведением внутрибрюшной гипертермической химиотерапии (hyperthermic intraperitoneal chemotherapy – HIPEC) является операцией выбора у определенных групп пациентов взрослого возраста. Циторедукцию и HIPEC выполняют взрослым пациентам с раком яичников, желудка, колоректальным раком, при карциноме червеобразного отростка, мезотелиоме брюшины и ряде опухолей других локализаций. В педиатрической популяции опыт применения циторедукции и HIPEC ограничен, так как у детей реже встречается распространение злокачественных опухолей по брюшине. В то же время до 30% всех злокачественных новообразований у детей развиваются в брюшной полости и полости малого таза; для них характерна высокая частота рецидивов, особенно при повреждении целостности опухоли. Учитывая невысокую встречаемость эпителиальных  карцином у детей, HIPEC находит большее применение у пациентов с другими типами злокачественных опухолей, таких как десмопластическая мелкокруглоклеточная опухоль, герминогенно-клеточные опухоли, рабдомиосаркомы и др. В данной работе представлен анализ мирового опыта применения циторедукции и HIPEC в педиатрической практике.

Об авторах

Д. Г. Ахаладзе
ФГБУ «Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева» Минздрава России
Россия

Контактная информация: Ахаладзе Дмитрий Гурамович, канд. мед. наук, руководитель группы торакоабдоминальной хирургии НМИЦ детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева Минздрава России.

Адрес: 117997, Москва, ГСП-7, ул. Саморы Машела, 1


Г. С. Рабаев
ФГБУ «Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева» Минздрава России
Россия
Москва


Н. С. Грачёв
ФГБУ «Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева» Минздрава России
Россия
Москва


Список литературы

1. Thomassen I., van Gestel Y.R., Lemmens V.E. Incidence, prognosis, and treatment options for patients with synchronous peritoneal carcinomatosis and liver metastases from colorectal origin. Dis Colon Rectum 2013; 56 (12): 1373–80. DOI: org/10.1097/DCR.0b013e3182a62d9d

2. Meigs J.V. Tumors of the female pelvic organs. New York: Macmillan; 1934.

3. Sugarbaker P.H. Peritonectomy procedures. Ann Sur1995; 221: 29–42.

4. Gilly F.N., Beaujard A., Glehen O., Caillot J.L., Francois Y., Sadeghi-Looyeh B., et al. Peritonectomy combined with intraperitoneal chemohyperthermia in abdominal cancer with peritoneal carcinomatosis: phase I–II study. Anticancer Res 1999; 19: 2317–21.

5. Glehen O., Cotte E., Kusamura S., Deraco M., Baratti D., Passot G., et al. Hyperthermic intraperitoneal chemotherapy: nomenclature and modalities of perfusion. J Surg Oncol 2008; 98: 242–6. DOI: 10.1002/jso.21061

6. Elias D., Antoun S., Goharin A., Otmany A.E., Puizillout J.M., Lasser P. Research on the best chemohyperthermia technique of treatment of peritoneal carcinomatosis after complete resection. Int J Surg Investig 2000; 1: 431–9.

7. Ceelen W., Flessner M. Intraperitoneal therapy for peritoneal tumors: biophysics and clinical evidence. Nat Rev Clin Oncol 2009; 2010 (7): 108–15. DOI: org/10.1038/nrclinonc.2009.217

8. Brucher B.L., Piso P., Verwaal V., Esquivel J., Derraco M., Yonemura Y. Peritoneal carcinomatosis: cytoreductive surgery and HIPEC—overview fnd basics. Cancer Investig 2012; 30: 209–24. DOI: 10.3109/07357907.2012.654871

9. Hildebrandt B., Wust P., Ahlers O., Sreenivasa G., Kerner T., Felix R., et al. The cellular and molecular basis of hyperthermia. Crit Rev Oncol Hematol 2002; 43: 33–56.

10. Coccolini F., Gheza F., Lotti M., Virzì S., Iusco D., Ghermandi C., et al. Peritoneal carcinomatosis. World J Gastroenterol 2013; 19 (41): 6979–94.

11. DOI: 10.3748/wjg.v19.i41.6979

12. Glehen O., Mithieux F., Osinsky D., Beaujard A.C., Freyer G., Guertsch P., et al. Surgery combined with peritonectomy procedures and intraperitoneal chemohyperthermia in abdominal cancers with peritoneal carcinomatosis: A phase II study. J Clin Oncol 2003; 21: 799–806. DOI: 10.1200/JCO.2003.06.139

13. Lambert L.A. Looking up: Recent advances in understanding and treating peritoneal carcinomatosis. CA Cancer J Clin 2015 Jul-Aug; 65 (4): 284–98. DOI: 10.3322/caac.21277

14. De Bree E., Romanos J., Michalakis J. Intraoperative hyperthermic intraperitoneal chemotherapy with docetaxel as second-line treatment for peritoneal carcinomatosis of gynaecological origin Anticancer Research 2003; 23 (3): 3019–27.

15. Verwaal V.J., Van Ruth S., De Bree E., van Sloothen G.W., van Tinteren H., Boot H., et al. Randomized trial of cytoreduction and hyperthermic intraperitoneal chemotherapy versus systemic chemotherapy and palliative surgery in patients with peritoneal carcinomatosis of colorectal cancer. J Clin Oncol 2003; 21 (20): 3737–43. DOI: 10.1200/JCO.2003.04.187

16. Yan T.D., Welch L., Black D., Sugarbaker P.H. A systematic review on the efficacy of cytoreductive surgery combined with perioperative intraperitoneal chemotherapy for diffuse malignancy peritoneal mesothelioma. Ann Oncol 2007; 18 (5): 827–34. DOI: 10.1093/annonc/mdl428

17. Glehen O., Passot G., Cotte E., Bakrin N. Peritoneal surface diseases. Hepato-Gastro and Oncologie Digestive 2014; 21 (8): 630–41. DOI: 10.1684/hpg.2014.1062

18. Sommariva A., Pilati P., Rossi C.R. Cyto-reductive Surgery combined with Hyperthermic Intra- peritoneal Chemotherapy for Peritoneal Surface Malignancies: current treatment and results. Cancer Treat Rev 2012; 38 (4): 258–68. DOI: 10.1016/j.ctrv.2011.07.001

19. Yan T.D., Deraco M., Baratti D., Kusamura S., Elias D., Glehen O., et al. Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for malignant peritoneal mesothelioma: Multi- institutional experience. J Clin Oncol 2009; 27 (36): 6237–42. DOI: 10.1200/JCO.2009.23.9640

20. Helm J.H., Miura J.T., Glenn J.A., Marcus R.K., Larrieux G., Jayakrishnan T.T., et al. Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Malignant Peritoneal Mesothelioma: A Systematic Review and Metaanalysis. Annals of Surgical Oncology 2015; 22 (5): 1686–93. DOI: 10.1245/s10434-014-3978-x

21. Sommariva A., Pilati P., Rossi C.R. Cyto-reductive Surgery combined with Hyperthermic Intra- peritoneal Chemotherapy for Peritoneal Surface Malignancies: current treatment and results. Cancer Treat Rev 2012; 38 (4): 258–68. DOI: 10.1016/j.ctrv.2011.07.001

22. McBride K., McFadden D., Osler T. Improved survival of patients with pseudomyxoma peritonei receiving intraperitoneal chemotherapy with cytoreductive surgery: A systematic review and meta-analysis. Journal of Surgical Research 2013; 183 (1): 246–52. DOI: 10.1016/j.jss.2012.12.040

23. Chua T.C., Moran B.J., Sugarbaker P.H., Levine E.A., Glehen O., Gilly F.N., et al. Early- and long-term outcome data of patients with pseudomyxoma peritonei from appendiceal origin treated by a strategy of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. J Clin Oncol 2012; 30 (20): 2449–56. DOI: 10.1200/JCO.2011.39.7166

24. Bryan M.L., Fitzgerald N.C., Levine E.A., Shen P., Stewart J.H., Votanopoulos K.I. Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy in sarcomatosis from gastrointestinal stromal tumor. Am Surg 2014; 80 (9): 890–5.

25. Al-Badawi I.A., Abu-Zaid A., Azzam A., Al-Omar O., AlHusaini H., Amin T. Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for man- agement of recurrent/relapsed ovarian granulosa cell tumor: a single-center experience. J Obstet Gynaecol Res 2014; 40 (9): 2066–75. DOI: 10.1111/jog.12460

26. Salti G., Ailabouni L., Undevia S. Cytoreductive sur- gery and hyperthermic intraperitoneal chemotherapy for the treatment of peritoneal sarcomatosis. Ann Surg Oncol 2012; 19 (5): 1410–5. DOI: 10.1245/s10434-012-2240-7

27. Van Oudheusden T.R., Lemmens V.E., Braam H.J. Peritoneal metastases from small bowel cancer: results of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in The Netherlands. Surgery 2015; 157 (6): 1023–7. DOI: 10.1016/j.surg.2015.01.021

28. Goéré D., Passot G., Gelli M., Levine E.A., Bartlett D.L., Sugarbaker P.H., et al. On behalf the PSOGI; BIG-RENAPE Working Groups. Complete cytore- ductive surgery plus HIPEC for peritoneal metasta- ses from unusual cancer sites of origin: results from a worldwide analysis issue of the peritoneal surface oncology group international (PSOGI). Int J Hyperth 2017; 8: 1–35. DOI: org/10.1080/02656736.2017. 1301576

29. Honore C., Goere D., Dartgues P., Burtin P., Dumont F., Elias D. Peritoneal Carcinomatosis from Solid Pseudopapillary Neoplasm (Frantz's Tumour) of the Pancreas Treated with HIPEC. Anticancer Research 2012; 32 (3): 1069–7.

30. Cytoreductive Surgery (CRS) With/Without HIPEC in Gastric Cancer With Peritoneal Carcinomatosis (GASTRIPEC). https://clinicaltrials.gov/ct2/show/NCT02158988

31. Adjuvant Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Versus no HIPEC in Locally Advanced Colorectal Cancer (APEC Study). https://clinicaltrials.gov/ct2/show/NCT02965248

32. Huh W.W., Fitzgerald N.E., Mahajan A., Hayes-Jordan A. Peritoneal sarcomatosis in pediatric malignancies. Pediatr Blood Cancer 2013; 60 (1): 12–7. DOI: 10.1002/pbc.24293

33. Hayes-Jordan A., Green H., Lin H., Owusu-Agyemang P., Mejia R., Okhuy-sen-Cawley R., et al. Cytoreductive surgery and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) for children, adolescents, and young adults: the first 50 cases. Ann Surg Oncol 2015; 22 (5): 1726–32. DOI: 10.1245/s10434-014-4289-y

34. Smith A.W., Seibel N.L., Lewis D.R., Albritton K.H., Blair D.F., Blanke C.D., et al. Next steps for adolescent and young adult oncology workshop: An update on progress and recommendations for the future. Cancer 2016; 122 (7): 988–99. DOI: 10.1002/cncr.29870

35. Barr R.D., Ferrari A., Ries L., Whelan J., Bleyer W.A. Cancer in adolescents and young adults: A narrative review of the current status and a view of the future. JAMA Pediatrics 2016; 170 (5): 495–501. DOI: 10.1001/jamapediatrics.2015.4689

36. Howell S.B., Pfeifle C.E., Olshen R.A. Intraperitoneal chemotherapy with melphalan. Ann Intern Med 1984; 101 (1): 14–8.

37. Hayes-Jordan A., Anderson P., Curley S., Herzog C., Lally K.P., Green H.L., et al. Continuous hyperthermic peritoneal perfusion for desmoplastic small round cell tumor. Journal of Pediatric Surgery 2007; 42 (8). DOI: 10.1016/j.jpedsurg.2007.05.047

38. Reingruber B., Boettcher M.I., Klein P., Hohenberger W., Peltz J.O.W. Hyperthermic intraperitoneal chemoperfusion is an option for treatment of peritoneal carcinomatosis in children. Journal of Pediatric Surgery 2007; 42 (9). DOI: 10.1016/j.jpedsurg.2007.06.009

39. Hayes-Jordan A., Green H.L., Lin H., Owusu-Agyemang P., Fitzgerald N., Arunkumar R., et al. Complete Cytoreduction and HIPEC Improves Survival in Desmoplastic Small Round Cell Tumor. Annals of Surgical Oncology 2014; 21 (1): 220–4. DOI: 10.1245/s10434-013-3269-y

40. Hayes-Jordan A., Lopez С., Green H.L. Cytoreductive Surgery (CRS) and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in Pediatric Ovarian Tumors: A Novel Treatment Approach Pediatr Surg Int. 2016 January ; 32(1): 71–73. DOI: 10.1007/s00383-015-3814-9

41. Schultz K.A.P., Sencer S.F., Messinger Y., Neglia J.P., Steiner M.E. Pediatric ovarian tumors: A review of 67 cases. Pediatric Blood & Cancer 2005; 44 (2): 167–73. DOI: 10.1002/pbc.20233

42. Hayes-Jordan A.A., Coakley B.A., Green H.L., Xiao L., Fournier K.F., Herzog C.E. et al. Desmoplastic Small Round Cell Tumor Treated with Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy: Results of a Phase 2 Trial. Annals of Surgical Oncology 2018; 25 (4): 872–7. DOI: 10.1245/s10434-018-6333-9

43. Subbiah V., Lamhamedi-Cherradi S.-E., Cuglievan, B., Menegaz B.A., Camacho P., Huh W., et al. Multimodality Treatment of Desmoplastic Small Round Cell Tumor: Chemotherapy and Complete Cytoreductive Surgery Improve Patient Survival. Clinical Cancer Research 2018. DOI: 10.1158/1078-0432.ccr-18-0202

44. Honoré C., Atallah V., Mir O., Orbach D., Ferron G., LePéchoux C., et al. Abdominal desmoplastic small round cell tumor without extraperitoneal metastases: Is there a benefit for HIPEC after macroscopically complete cytoreductive surgery? PLoS ONE 2017; 12 (2): e0171639. DOI: 10.1371/journal.pone.0171639

45. Bautista F., Elias D., Pasqualini C. Hyperthermic intraperitoneal chemotherapy after cytoreductive surgery for the treatment of peritoneal carcinomatosis in pediatric solid malignancies: a single institution experience. Journal of Pediatric Surgery 2014; 49 (8): 1276–9. DOI: 10.1016/j.jpedsurg.2014.01.054.

46. Rodríguez Silva C., Moreno Ruiz F.J., Bellido Estévez I., Carrasco Campos J., Titos García A., Ruiz López M., et al. Are there intra-operative hemodynamic differences between the Coliseum and closed HIPEC techniques in the treatment of peritoneal metastasis? A retrospective cohort study. World J Surg Oncol 2017; 15 (1): 51.2017 Feb 21. DOI: 10.1186/s12957-017-1119-2

47. Scalabre A., Philippe-Chomette P., Passot G., Orbach D., Elias D., Corradini N., et al.Cytoreductive surgery and hyperthermic intraperitoneal perfusion with chemotherapy in children with peritoneal tumor spread: A French nationwide study over 14 years. Pediatric Blood & Cancer 2018; 65 (4): e26934. DOI:10.1002/pbc.26934

48. Dueck A.C., Mendoza T.R., Mitchell S.A., Reeve B.B., Castro K.M., Rogak L.J., et al. Validity and Reliability of the US National Cancer Institute's Patient-Reported Outcomes Version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE). JAMA Oncol 2015; 1 (8): 1051–9 DOI: 10.1001/jamaoncol.2015.2639

49. Gesche J., Beckert S., Neunhoeffer F., Kachanov D., Königsrainer A., Seitz G., et al. Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: A safe treatment option for intraperitoneal rhabdomyosarcoma in children below 5 years of age. Pediatric Blood & Cancer 2018; e27517. DOI: 10.1002/pbc.27517

50. Winer L., Macedo F.I., Alfawaz A., Sommariva A., Cecchetto G., Podda A., et al. Novel Therapy for Pediatric Angiosarcoma With Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy J Pediatr Hematol Oncol 2018 Nov; 40 (8): e505–e510. DOI: 10.1097/MPH.0000000000001231

51. Zmora O., Hayes-Jordan A., Nissan A., Kventsel I., Newmann Y., Itskovsky K., et al. Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) for disseminated intra-abdominal malignancies in children – a single-institution experience. Journal of Pediatr Surgery 2018; 53 (7): 1381–6. DOI: 10.1016/j.jpedsurg.2017.09.014

52. Dhir M., Ramalingam L., Shuai Y., Pakrafter S., Jones H.L., Hogg M.E. Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemoperfusion in Adolescent and Young Adults with Peritoneal Metastases. Ann of Surgical Oncology 2016: 1–9. DOI: 10.1245/s10434-016-5689-y

53. Hayes-Jordan A., Green H., Ludwig J., Anderson P. Toxicity of hyperthermic intraperitoneal chemotherapy (HIPEC) in pediatric patients with sarcomatosis/carcinomatosis: early experience and phase 1 results. Pediatr Blood Cancer 2012; 59 (2): 395–7. DOI: 10.1002/pbc.24160

54. Womack A.M., Hayes-Jordan A., Pratihar R., Barringer D.A., Hall J.H.Jr., Gidley P.W., et al. Evaluation of ototoxicity in patients treated with hyperthermic intraperitoneal chemotherapy (HIPEC) with cisplatin and sodium thiosulfate. Ear Hear 2014; 35 (6): e243–7. DOI: 10.1097/AUD.0000000000000070

55. Ortega-Deballon P., Glehen O., Levine E., Piso P., Sugarbaker P.H., Hayes-Jordan A., et al. Childbearing after hyperthermic intraperitoneal chemotherapy: results from an international survey. Ann Surg Oncol 2011; 18 (8): 2297–301. DOI: 10.1245/s10434-011-1595-5


Для цитирования:


Ахаладзе Д.Г., Рабаев Г.С., Грачёв Н.С. Циторедуктивные операции и внутрибрюшная гипертермическая химиоперфузия у детей. Вопросы гематологии/онкологии и иммунопатологии в педиатрии. 2019;18(4):118-126. https://doi.org/10.24287/1726-1708-2019-18-4-118-126

For citation:


Akhaladze D.G., Rabaev G.S., Grachev N.S. Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in children. Pediatric Hematology/Oncology and Immunopathology. 2019;18(4):118-126. (In Russ.) https://doi.org/10.24287/1726-1708-2019-18-4-118-126

Просмотров: 253


Creative Commons License
Контент доступен под лицензией Creative Commons Attribution 4.0 License.


ISSN 1726-1708 (Print)
ISSN 2414-9314 (Online)