Циторедуктивные операции и внутрибрюшная гипертермическая химиоперфузия у детей

Циторедуктивное оперативное вмешательство с проведением внутрибрюшной гипертермической химиотерапии (hyperthermic intraperitoneal chemotherapy – HIPEC) является операцией выбора у определенных групп пациентов взрослого возраста. Циторедукцию и HIPEC выполняют взрослым пациентам с раком яичников, желудка, колоректальным раком, при карциноме червеобразного отростка, мезотелиоме брюшины и ряде опухолей других локализаций. В педиатрической популяции опыт применения циторедукции и HIPEC ограничен, так как у детей реже встречается распространение злокачественных опухолей по брюшине. В то же время до 30% всех злокачественных новообразований у детей развиваются в брюшной полости и полости малого таза; для них характерна высокая частота рецидивов, особенно при повреждении целостности опухоли. Учитывая невысокую встречаемость эпителиальных  карцином у детей, HIPEC находит большее применение у пациентов с другими типами злокачественных опухолей, таких как десмопластическая мелкокруглоклеточная опухоль, герминогенно-клеточные опухоли, рабдомиосаркомы и др. В данной работе представлен анализ мирового опыта применения циторедукции и HIPEC в педиатрической практике.

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