Случай развития вторичного миелоидного лейкоза у пациента с нейробластомой

Современные успехи детской онкологии улучшили показатели выживаемости пациентов с нейробластомой (НБ) группы промежуточного и высокого риска. В то же время интенсивная мультимодальная терапия приводит к увеличению частоты встречаемости вторичных злокачественных новообразований у выживших пациентов. В настоящее время известно, что алкилирующие агенты, ингибиторы топоизомеразы II и препараты платины могут приводить к развитию вторичного острого миелоидного лейкоза (ОМЛ). В данной статье представлены литературный обзор и описание клинического случая развития вторичного ОМЛ через 57 мес от установления первичного диагноза у пациента с НБ группы промежуточного риска, получавшего интенсивную химиотерапию в 1-й линии и в рецидиве заболевания. Дебют вторичного ОМЛ потребовал выполнения ряда диагностических исследований для исключения рецидива НБ. Родители дали согласие на использование информации, в том числе фотографий ребенка, в научных исследованиях и публикациях.

нейробластома, дети, вторичные злокачественные опухоли, вторичный острый миелоидный лейкоз

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