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GD2-направленная иммунотерапия нейробластомы группы высокого риска с использованием химерных антител ch14.18

https://doi.org/10.24287/1726-1708-2020-19-3-173-188

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Аннотация

Нейробластома является наиболее частой экстракраниальной солидной опухолью у детей от 0 до 14 лет. Современные риск-адаптированные программы лечения основаны на выделении 3 групп риска. В группу высокого риска стратифицируются 40–50% пациентов. Прогноз у пациентов группы высокого риска остается неблагоприятным (вероятность долгосрочной выживаемости менее 50%), несмотря на применение агрессивной мультимодальной терапии, включающей высокодозную химиотерапию и аутологичную трансплантацию гемопоэтических стволовых клеток. В большинстве случаев опухолевые клетки при нейробластоме экспрессируют дисиалоганглиозид GD2, рассматривающийся как возможная мишень для проведения иммунотерапии. На протяжении последних 30 лет были разработаны и внедрены в клиническую практику GD2-направленные химерные моноклональные антитела ch14.18. Целым рядом клинических исследований было показано улучшение прогноза у пациентов с нейробластомой группы высокого риска при использовании моноклональных антител ch14.18, в первую очередь за счет эрадикации минимальной остаточной популяции опухолевых клеток, резистентных к стандартной химиотерапии. Настоящий обзор литературы обобщает международный опыт применения моноклональных антител ch14.18 от ранних фаз клинических исследований до крупных рандомизированных исследований, позволивших рассматривать иммунотерапию как важный компонент мультимодальной терапии нейробластомы группы высокого риска. Рассмотрены перспективы применения и место иммунотерапии в первой линии терапии у пациентов с нейробластомой группы высокого риска и у больных с рецидивами заболевания.

Об авторах

Т. В. Шаманская
ФГБУ «Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева» Минздрава России
Россия
117997, Москва, ул. Саморы Машела, 1


Н. А. Андреева
ФГБУ «Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева» Минздрава России
Россия
117997, Москва, ул. Саморы Машела, 1


Д. Т. Уталиева
ФГБУ «Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева» Минздрава России
Россия
117997, Москва, ул. Саморы Машела, 1


Д. Ю. Качанов
ФГБУ «Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева» Минздрава России
Россия

д-р мед. наук, заведующий отделением клинической онкологии, заместитель директора Института онкологии, радиологии и ядерной медицины,

117997, Москва, ул. Саморы Машела, 1 



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Для цитирования:


Шаманская Т.В., Андреева Н.А., Уталиева Д.Т., Качанов Д.Ю. GD2-направленная иммунотерапия нейробластомы группы высокого риска с использованием химерных антител ch14.18. Вопросы гематологии/онкологии и иммунопатологии в педиатрии. 2020;19(3):173-178. https://doi.org/10.24287/1726-1708-2020-19-3-173-188

For citation:


Shamanskaya T.V., Andreeva N.A., Utalieva D.T., Kachanov D.Yu. Anti-GD2 immunotherapy with the chimeric antibody ch14.18 for high-risk neuroblastoma. Pediatric Hematology/Oncology and Immunopathology. 2020;19(3):173-178. (In Russ.) https://doi.org/10.24287/1726-1708-2020-19-3-173-188

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ISSN 1726-1708 (Print)
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