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Вопросы гематологии/онкологии и иммунопатологии в педиатрии

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Case Report of Mesenteric Lymphadenopathy in Gaucher Disease: Rare and Benign Complication

Аннотация

A 10-year-old boy known case of Gaucher’s disease about 2 years ago was admitted with nausea, vomiting and epigastric pain from 3 days before hospitalization to Mofid Children’s hospital, Tehran, Iran. On the initial examination, no abnormalities were found except for splenomegaly and brief tenderness on the spleen. In secondary paraclinical evaluations (with Ultrasound and Ct-scan), we noticed mesenteric lymphadenopathy in the patient.  The lesions remained unchanged and no significant changes were observed in the clinical and laboratory evaluations of the patient during one-year follow-up period. This is a rare and benign manifestation of Gaucher’s disease, which is usually monitored and does not require any intervention without signs of malignancy or severe space‑occupying effects   

Об авторах

Mitra Khalili
Assistant Professor of Radiology, Department Of Radiology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Иран


Mehdi Gholamzadeh Baeis
Department of Radiology, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Иран


Mohammad Reza Alaei
Department of Pediatric Endocrinology and Metabolism, Mofid Children's Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Иран


Список литературы

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2. Ye Z-X, Gao X, Qu Q, Ye X, He X-D. Gaucher Disease with Mesenteric Lymphadenopathy: A Case with 13-year Follow-up. Chinese medical journal. 2016;129(20):2502-3.

3. Simpson EA, Jaring MR, Andronikou S. Massive Mesenteric Lymphadenopathy Causing Protein-losing Enteropathy in Gaucher Disease. Journal of pediatric hematology/oncology. 2017;39(5):e300-e1.

4. Lee BH, Kim DY, Kim GH, Cho KJ, Yoon HK, Yoo HW. Progressive mesenteric lymphadenopathy with protein-losing enteropathy; a devastating complication in Gaucher disease. Molecular genetics and metabolism. 2012;105(3):522-4.

5. Abdelwahab M, SeifEldien HM. Mesenteric and Mediastinal Lymphadenopathy in Egyptian Children With Gaucher Disease Types 1 and 3 Treated With Enzyme Replacement Therapy. Journal of pediatric hematology/oncology. 2015;37(5):e316-22.

6. Burrow TA, Cohen MB, Bokulic R, Deutsch G, Choudhary A, Falcone RA, Jr., et al. Gaucher disease: progressive mesenteric and mediastinal lymphadenopathy despite enzyme therapy. The Journal of pediatrics. 2007;150(2):202-6.

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Рецензия

Для цитирования:


., ., . . Вопросы гематологии/онкологии и иммунопатологии в педиатрии. 2021;20(1).

For citation:


Khalili M., Gholamzadeh Baeis M., Alaei M. Case Report of Mesenteric Lymphadenopathy in Gaucher Disease: Rare and Benign Complication. Pediatric Hematology/Oncology and Immunopathology. 2021;20(1). (In Russ.)

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ISSN 1726-1708 (Print)
ISSN 2414-9314 (Online)