Прогностические маркеры лимфобластной лимфомы

Лимфобластная лимфома (ЛБЛ) – вторая по частоте встречаемости неходжкинская лимфома у детей. Согласно современным представлениям, ЛБЛ и острый лимфобластный лейкоз (ОЛЛ) рассматривают как проявления одного и того же заболевания, учитывая сходный морфологический субстрат опухоли – Т- и В-лимфобласты. Стандартом терапии ЛБЛ в настоящее время являются ОЛЛ-подобные риск-адаптированные протоколы лечения, позволяющие добиться показателей общей и бессобытийной выживаемости, достигающие 80–90%. Разделение на группы риска основано на стадии заболевания и ответе на терапию индукции. Однако проблема рецидивов/ рефрактерного течения заболевания остается серьезной ввиду отсутствия достаточно эффективных терапевтических опций. На сегодняшний день имеется достаточное количество клинических данных, достоверно показывающих, что ряд молекулярно-биологических факторов может быть использован для создания новой системы стратификации на группы риска пациентов с ЛБЛ. Настоящий обзор посвящен анализу различных факторов, которые могут быть ответственны за прогноз ЛБЛ у детей.

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