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Вопросы гематологии/онкологии и иммунопатологии в педиатрии

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Современная терапия инфантильных гемангиом

https://doi.org/10.24287/1726-1708-2021-20-2-156-167

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Аннотация

Инфантильная гемангиома (ИГ) – это самая частая доброкачественная сосудистая опухоль детей первого года жизни, в основе которой лежит аномальная пролиферация эндотелиальных клеток под действием основных проангиогенных факторов: фактора роста эндотелия сосудов (VEGF) и фактора роста фибробластов (FGF). Она развивается в первые недели после рождения, формируясь на протяжении 3–9 мес с регрессом в последующие 3–7 лет. Три четверти ИГ имеют нодулярную форму и не сопровождаются мальформациями, в то время как сегментарные ИГ чаще всего ассоциированы с синдромальными формами. Несмотря на спонтанный регресс (в 90% случаев), некоторые формы и локализации ИГ могут приводить к развитию осложнений как локальных, так и ставящих под угрозу витальные функции. В подавляющем большинстве случаев диагноз основывается на данных анамнеза, характерных признаках опухоли и клинического течения. Дополнительные исследования (ультразвуковая доплерография, магнитно-резонансная томография/компьютерная томография, биопсия) необходимы при осложненных формах и в сомнительных клинических случаях.

Об авторах

Л. А. Хачатрян
ФГБУ «Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева» Минздрава России
Россия

Хачатрян Лили Альбертовна, канд. мед. наук, заведующая 
боксированным отделением гематологии онкологии 

117997, Москва, ул. Саморы Машела, 1



Д. М. Николаева
ФГБУ «Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева» Минздрава России
Россия

117997, Москва, ул. Саморы Машела, 1



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Для цитирования:


Хачатрян Л.А., Николаева Д.М. Современная терапия инфантильных гемангиом. Вопросы гематологии/онкологии и иммунопатологии в педиатрии. 2021;20(2):156-167. https://doi.org/10.24287/1726-1708-2021-20-2-156-167

For citation:


Khachatryan L.A., Nikolaeva D.M. Modern treatment of infantile hemangioma. Pediatric Hematology/Oncology and Immunopathology. 2021;20(2):156-167. (In Russ.) https://doi.org/10.24287/1726-1708-2021-20-2-156-167

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ISSN 1726-1708 (Print)
ISSN 2414-9314 (Online)