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Вопросы гематологии/онкологии и иммунопатологии в педиатрии

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Prognostic Evaluation For Immune Thrombocytopenia Outcome In Egyptian Children: A Retrospective Single Center Experience.

Аннотация

Objective: Immune thrombocytopenic purpura (ITP) is the most common cause of thrombocytopenia in children. This retrospective study was designed to Analyze presenting features of ITP cases in Benha, evaluate outcomes among children and Determine the prognostic factors like age, gender, residency, history of preceding vaccination and infection, complaint, initial platelet count and initial treatment modalities as guidelines for new cases at the time of diagnosis.

Method: Records of 308 children with ITP in Benha University Hospitals and Benha Children Hospital haematology clinics between May 2014 and January 2021 were retrospectively analyzed. Socio-demographic, clinical, and laboratory data of the studied children were recorded like age, gender, residence, date of diagnosis, complaint at presentation, preceding vaccination or infection, type of bleeding, initial platelet count, LDH(lactate dehydrogenase) level, initial treatment, and follow up of the disease.

Results: A total of 308 children diagnosed with ITP were included in our study, clinical courses were determined as acute and chronic in 71.4% and 28.6% respectively. The median age of patients on diagnosis was 5 ± 3.4 years. The male/female ratio was 1.14. Median age at diagnosis was significantly higher in chronic ITP (p<0.001), Patients with age ≥10 years developed chronicity more than younger cases (p=0.029). Regarding residency, seasonality, type of bleeding and history of preceding infection or vaccination, the difference was not statistically significant. Platelet count >20 ×109 was significantly higher in chronic ITP(P<0.001). LDH level at presentation was significantly higher in chronic cases (p=0.046). Initial lines of treatment of patients admitted were steroids in 88%, IVIG in 5.2%, IVIG with steroids in 2.9% while 3.9% didn't receive any treatment, there was no significant difference in outcome between initial lines of treatment(P=0.105).

Conclusion: In our study, age >10 years, females, Initial high platelet count and high LDH level at presentation were found to increase the probability of chronic ITP.

Keywords: p

Objective: Immune thrombocytopenic purpura (ITP) is the most common cause of thrombocytopenia in children. This retrospective study was designed to Analyze presenting features of ITP cases in Benha, evaluate outcomes among children and Determine the prognostic factors like age, gender, residency, history of preceding vaccination and infection, complaint, initial platelet count and initial treatment modalities as guidelines for new cases at the time of diagnosis.

Method: Records of 308 children with ITP in Benha University Hospitals and Benha Children Hospital haematology clinics between May 2014 and January 2021 were retrospectively analyzed. Socio-demographic, clinical, and laboratory data of the studied children were recorded like age, gender, residence, date of diagnosis, complaint at presentation, preceding vaccination or infection, type of bleeding, initial platelet count, LDH(lactate dehydrogenase) level, initial treatment, and follow up of the disease.

Results: A total of 308 children diagnosed with ITP were included in our study, clinical courses were determined as acute and chronic in 71.4% and 28.6% respectively. The median age of patients on diagnosis was 5 ± 3.4 years. The male/female ratio was 1.14. Median age at diagnosis was significantly higher in chronic ITP (p<0.001), Patients with age ≥10 years developed chronicity more than younger cases (p=0.029). Regarding residency, seasonality, type of bleeding and history of preceding infection or vaccination, the difference was not statistically significant. Platelet count >20 ×109 was significantly higher in chronic ITP(P<0.001). LDH level at presentation was significantly higher in chronic cases (p=0.046). Initial lines of treatment of patients admitted were steroids in 88%, IVIG in 5.2%, IVIG with steroids in 2.9% while 3.9% didn't receive any treatment, there was no significant difference in outcome between initial lines of treatment(P=0.105).

Conclusion: In our study, age >10 years, females, Initial high platelet count and high LDH level at presentation were found to increase the probability of chronic ITP.

Keywords: primary ITP, ITP outcome, ITP prognostic factors.

Abbervations: ITP : Immune thrombocytopenic purpura; LDH: lactate dehydrogenase

Abbervations: ITP : Immune thrombocytopenic purpura; LDH: lactate dehydrogenase

Об авторе

Aliaa Diab
Behan university hospital
Египет


Список литературы

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. . Вопросы гематологии/онкологии и иммунопатологии в педиатрии. 2021;20(3).

For citation:


Diab A. Prognostic Evaluation For Immune Thrombocytopenia Outcome In Egyptian Children: A Retrospective Single Center Experience. Pediatric Hematology/Oncology and Immunopathology. 2021;20(3).

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ISSN 1726-1708 (Print)
ISSN 2414-9314 (Online)