Вопросы гематологии/онкологии и иммунопатологии в педиатрии

Расширенный поиск

Solitary cutaneous mastocytoma on the scalp of a child; a case report and review of literature

Полный текст:


   Mastocytomas are solitary mast cell tumors that are generally seen on the trunk and extremities. Childhood-onset mastocytomas of the scalp are extremely rare. We report a case of a one-and-a-half-year-old toddler boy that presented with a yellow-brown plaque on his scalp. Pathological evaluation s revealed mast cell accumulation in the upper dermis. These cells were uniform with a fried-egg appearance and had visible cytoplasmic granules with Wright-Giemsa staining. This study demonstrates the difficulty of diagnosing soli¬tary mastocytomas as it is a very rare disease and has non-specific clinical findings. In this study, a child with a rare solitary cutaneous mastocytoma on the scalp was evaluated and a review of previous literature was conducted.

Об авторах

M. Bahadoram
Ahvaz Jundishapur University of Medical Sciences

Mohammad Bahadoram


Y. Joonaki
Ahvaz Jundishapur University of Medical Sciences

Younes Joonaki

Department of Dermatology


R. Yaghoobi
Ahvaz Jundishapur University of Medical Sciences

Reza Yaghoobi

Department of Dermatology


M.-R. Mahmoudian-Sani
Ahvaz Jundishapur University of Medical Sciences

Mohammad-Reza Mahmoudian-Sani


S. Hassanzadeh
Ahvaz Jundishapur University of Medical Sciences

Shakiba Hassanzadeh, MD

Thalassemia and Hemoglobinopathy Research Center,


S. Bahadoram
Ahvaz Jundishapur University of Medical Sciences

Sara Bahadoram


Список литературы

1. Wagner N., Staubach P. Mastocytosis–pathogenesis, clinical manifestation and treatment. J Dtsch Dermatol Ges 2018; 16 (1): 42–57. DOI: 10.1111/ddg.13418

2. Metcalfe D. D., Mekori Y. A. Pathogenesis and pathology of mastocytosis. Annu Rev Pathol 2017; 12: 487–514. DOI: 10.1146/annurev-pathol-052016-100312

3. Rossignol J., Polivka L., Maouche-Chrétien L., Frenzel L., Dubreuil P., Hermine O. Recent advances in the understanding and therapeutic management of mastocytosis. F1000Res 2019; 8: F1000 Faculty Rev-961. DOI: 10.12688/f1000research.19463.1

4. Pardanani A. Systemic mastocytosis in adults: 2019 update on diagnosis, risk stratification and management. Am J Hematol 2019; 94 (3): 363–77. DOI: 10.1002/ajh.25371

5. Horny H. P., Reiter A., Sotlar K., Valent P. Mastocytosis. Encyclopedia of Pathology. Springer, Cham; 2018. Р. 1–11.

6. Valent P., Akin C., Metcalfe D. D. Mastocytosis: 2016 updated WHO classification and novel emerging treatment concepts. Blood 2017; 129 (11): 1420–7. DOI: 10.1182/blood-2016-09-731893

7. Matito A., Azana J. M., Torrelo A., Alvarez-Twose I. Cutaneous Mastocytosis in Adults and Children: New Classification and Prognostic Factors. Immunol Allergy Clin North Am 2018; 38 (3): 351–63.

8. Ahmed A., Jan A. Mastocytoma. Stat Pearls. Treasure Island (FL): Stat Pearls Publishing Copyright © 2020, StatPearls Publishing LLC.; 2020.

9. Frieri M., Quershi M. Pediatric Mastocytosis: A Review of the Literature. Pediatr Allergy Immunol Pulmonol 2013; 26 (4): 175–80.

10. Srinivas S., Dhar S., Parikh D. Mastocytosis in children. Indian J Paediatr Dermatol 2015; 16 (2): 57–63.

11. Leung A. K., Lam J. M., Leong K. F. Childhood solitary cutaneous mastocytoma: clinical manifestations, diagnosis, evaluation, and management. Curr Pediatr Rev 2019; 15 (1): 42–6. DOI: 10.2174/1573396315666181120163952

12. Gopal D., Puri P., Singh A., Ramesh V. Asymptomatic solitary cutaneous mastocytoma: a rare presentation. Indian J Dermatol 2014; 59 (6): 634. DOI: 10.4103/0019-5154.143588

13. Castells M., Metcalfe D. D., Escribano L. Diagnosis and treatment of cutaneous mastocytosis in children: practical recommendations. Am J Clin Dermatol 2011; 12 (4): 259–70.

14. Górska A., Niedoszytko M., Lange M., Chełmińska M., Nedoszytko B., Wasąg B., et al. Risk factors for anaphylaxis in patients with mastocytosis. Pol Arch Med Wewn 2015; 125 (1–2): 46–53.

15. Czarny J., Lange M., Ługowska-Umer H., Nowicki R. J. Cutaneous mastocytosis treatment: strategies, limitations and perspectives. Postepy Dermatol Alergol 2018; 35 (6): 541–5.

16. Siebenhaar F., Akin C., Bindslev-Jensen C., Maurer M., Broesby-Olsen S. Treatment strategies in mastocytosis. Immunol Allergy Clin North Am 2014; 34 (2): 433–47.

17. Escribano L., Akin C , Castells M , Schwartz L B. Current options in the treatment of mast cell mediator-related symptoms in mastocytosis. Inflamm Allergy Drug Targets 2006; 5 (1): 61–77. DOI: 10.2174/187152806775269303

18. Vaes M., Benghiat F. S., Hermine O. Targeted Treatment Options in Mastocytosis. Front Med (Lausanne) 2017; 4: 110. DOI: 10.3389/fmed.2017.00110

19. Valent P., Akin C., Gleixner K. V., Sperr W. R., Reiter A., Arock M., et al. Multidisciplinary Challenges in Mastocytosis and How to Address with Personalized Medicine Approaches. Int J Mol Sci 2019; 20 (12): 2976.

20. Lange M., Nedoszytko B., Górska A., Żawrocki A., Sobjanek M., Kozlowski D. Mastocytosis in children and adults: clinical disease heterogeneity. Arch Med Sci 2012; 8 (3): 533.

21. Ma D., Stence A. A., Bossler A. B., Hackman J. R., Bellizzi A. M. Identification of KIT activating mutations in paediatric solitary mastocytoma. Histopathology 2014; 64 (2): 218–25.

22. Tüysüz G., Özdemir N., Apak H., Kutlubay Z., Demirkesen C., Celkan T. Childhood mastocytosis: results of a single center. Turk Pediatri Ars 2015; 50 (2): 108–13. DOI: 10.5152/tpa.2015.2332

23. Sula B. Two Different Face of Mastocytoma: Case Report. J Pediatr Neonatal Care 2015; 2.

24. Ha N. H., Lee Y. J., Park M. C., Lee I. J., Kim S. M., Park D. H. Solitary mastocytoma presenting at birth. Arch Craniofacial Surg 2018; 19 (2): 127.

25. Park M. N., Kim G. A., Chey M. J., Shim G. H. A case of diffuse cutaneous mastocytosis in a newborn. Korean J Perinatol 2014; 25 (2): 105–9.

26. Leung A. K., Barankin B., Leong K. F. A 6-week-old Girl with Recurrent Bullous Lesions and Erosions. Pediatr Rev 2019; 40 (Suppl 1): 34.

27. Yilmaz E. A., Orhan D., Andiran F., Soyer O. Rare cause of recurrent urticaria in childhood and its unusual presentation: Solitary mastocytoma on vulva. J Dermatol 2017; 2 (44): 213–4.

28. Kolivras A., André J., Thompson C., Sass U., Fraitag S. Pseudoangiomatous xanthelasmoid mastocytosis: two case reports showing the hypervascularity of this rare variant of cutaneous mastocytosis. J Cutan Pathol 2016; 43 (4): 388–93.


Для цитирования:

Bahadoram M., Joonaki Y., Yaghoobi R., Mahmoudian-Sani M., Hassanzadeh S., Bahadoram S. Solitary cutaneous mastocytoma on the scalp of a child; a case report and review of literature. Вопросы гематологии/онкологии и иммунопатологии в педиатрии. 2022;21(2):118-121.

For citation:

Bahadoram M., Joonaki Y., Yaghoobi R., Mahmoudian-Sani M., Hassanzadeh S., Bahadoram S. Solitary cutaneous mastocytoma on the scalp of a child; a case report and review of literature. Pediatric Hematology/Oncology and Immunopathology. 2022;21(2):118-121.

Просмотров: 291

Creative Commons License
Контент доступен под лицензией Creative Commons Attribution 4.0 License.

ISSN 1726-1708 (Print)
ISSN 2414-9314 (Online)