Вклад электронной микроскопии в исследование нарушений морфологии тромбоцитов

В данной статье рассматривается роль электронной микроскопии в диагностике и изучении морфологических изменений при врожденных заболеваниях, вызывающих нарушения строения тромбоцитов. Морфологические нарушения могут быть разделены на патологии цитоскелета тромбоцитов, альфа- и плотных гранул, а также изменения мембраны. В обзоре описываются ультраструктурные дефекты тромбоцитов при синдроме Вискотта–Олдрича, MYH9-ассоциированных синдромах, синдроме серых тромбоцитов, синдроме Германского–Пудлака, синдроме Пари–Труссо и синдроме Чедиака–Хигаши.

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