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The treatment of multiple organ dysfunction syndrome caused by gram-negative sepsis in a patient with neutropenia after allogeneic hematopoietic stem cell transplantation: a case report

https://doi.org/10.24287/1726-1708-2020-19-2-170-176

Abstract

Patients with high-dose chemotherapy-induced immunosuppression are at high risk for infectious complications with multiple organ dysfunction, which may lead to significantly higher mortality. We report a clinical case of multiple organ dysfunction syndrome caused by gram-negative septic shock in a child after allogeneic hematopoietic stem cell transplantation. We describe intensive care treatment modalities employed at different stages of therapy as well as the specifics of vital signs monitoring. The patient's parents gave their consent to the use of their child's data, including photographs, for research purposes and in publications.

About the Authors

A. Yu. Ivanashkin
Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology of Ministry of Healthcare of the Russian Federation
Russian Federation

Anesthesiologist-Intensivist at the Intensive Care Unit,

Russia, 117997, Moscow, Samory Mashela st., 1



V. V. Lazarev
Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology of Ministry of Healthcare of the Russian Federation; N.I. Pirogov Russian National Research Medical University of Ministry of Healthcare of the Russian Federation
Russian Federation


I. G. Khamin
Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology of Ministry of Healthcare of the Russian Federation
Russian Federation


I. A. Semenov
Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology of Ministry of Healthcare of the Russian Federation
Russian Federation


L. N. Shelikhova
Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology of Ministry of Healthcare of the Russian Federation
Russian Federation


A. A. Maschan
Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology of Ministry of Healthcare of the Russian Federation
Russian Federation


References

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2. Turki A.T., Lamm W., Schmitt C., Bayraktar E., Alashkar F., Metzenmacher M., et al. Platelet number and graft function predict intensive care survival in allogeneic stem cell transplantation patients. Ann Hematol, 2019; 98 (2): 491–500.

3. Gorbach S., Bartlett J., Blacklow N. Infectious diseases in medicine and surgery. Philadelphia: W.B. Saunders; 1998:903–9.

4. Brunkhorst F.M., Clark A.L., Forycki Z.F., Anker S.D. Pyrexia, procalcitonin, immune activation and survival in cardiogenic shock: the potential importance of bacterial translocation. Int J Cardiol 1999; 72: 310.

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6. Matics T.J, Sanchez-Pinto L.N. Adaptation and validation of a pediatric sequential organ failure assessment score and evaluation of the Sepsis-3 definitions in critically ill children. JAMA Pediatr 2017; 171 (10): e172352.


Review

For citations:


Ivanashkin A.Yu., Lazarev V.V., Khamin I.G., Semenov I.A., Shelikhova L.N., Maschan A.A. The treatment of multiple organ dysfunction syndrome caused by gram-negative sepsis in a patient with neutropenia after allogeneic hematopoietic stem cell transplantation: a case report. Pediatric Hematology/Oncology and Immunopathology. 2020;19(2):170-176. (In Russ.) https://doi.org/10.24287/1726-1708-2020-19-2-170-176

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ISSN 1726-1708 (Print)
ISSN 2414-9314 (Online)