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Methemoglobinemias in children (Review of literature and a clinical case report of a child with hemoglobin M Saskatoon)

https://doi.org/10.24287/1726-1708-2015-14-4-32-36

Abstract

A rare clinical case is discussed: congenital structural methemoglobinemia caused by hemoglobin M Saskatoon. The main clinical and laboratory markers of methemoglobinemia are described in detail. Photographs, hemolysate electrophoregram, and hemoglobin chain chromatogram are presented.

About the Authors

A. Yu. Usryugov
Federal Research Center of Pediatric Hematology, Oncology, and Immunology named after Dmitry Rogachev; Russian National Research Medical University named after N.I. Pirogov
Russian Federation


E. G. Kazanets
Federal Research Center of Pediatric Hematology, Oncology, and Immunology named after Dmitry Rogachev
Russian Federation


G. S. Zakharova
Federal Research Center of Pediatric Hematology, Oncology, and Immunology named after Dmitry Rogachev
Russian Federation


S. A. Plyasunova
Federal Research Center of Pediatric Hematology, Oncology, and Immunology named after Dmitry Rogachev
Russian Federation


I. O. Sadelov
Federal Research Center of Pediatric Hematology, Oncology, and Immunology named after Dmitry Rogachev
Russian Federation


References

1. Wright RO, Lewander WJ, Woolf AD. Methemoglobinemia: etiology, pharmacology and clinical management. Ann Emerg Med. 1999; 34(5): 646-56.

2. Kinoshita A, Nakayama Y, Kitayamat T, Tomita M. Simulation study of methemoglobin reduction in erythrocytes. Differential contributions of two pathways to tolerance to oxidative stress. FEBS J. 2007; 274(6): 1449-58.

3. Percy MJ, Lappin TR. Recessive congenital methaemoglobinaemia: cytochrome b(5)reductase deficiency. Br J Haematol. 2008; 141(3): 298-308.

4. Kugler W, Pekrun A, Laspe P, Erdlenbruch B, Lakomek M. Molecular basis of recessive congenital methemoglobinemia, types I and II: exon skipping and three novel missense mutations in the NADH-cytochrome b5 reductase (diaphorase 1) gene. Hum Mutat. 2001; 17(4): 348.

5. Ewenczyk C, Leroux A, Roubergue A, Laugel V, Afenjar A, Saudubray JM, et al. Recessive hereditary methaemoglobinemia, type II: delineation of the clinical spectrum. Brain. 2008; 131(3): 760-1.

6. Bando S, Takano T, Yubisui T, Shirabe K, Takeshita M, Nakagawa A. Structure of human erythrocyte NADH-cytochrome b5 reductase. Acta Crystallogr D Biol Crystallogr. 2004; 60(11): 1929-34.

7. Higgins C. Causes and clinical significance of increased methaemoglobin. Am J Physiol. 1942; 137: 56-8.

8. Huismann THJ, Carver MFH, Efremov GDA. Syllabus of hemoglobin variants. 2nd ed. USA Augusta, GA: The Sickle Cell Anemia Foundation, 1998.

9. Thom CS, Dickson CF, Gell DA, Weiss MJ. Hemoglobin variants: biochemical properties and clinical correlates. Cold Spring Harb Perspect Med. 2013; 3(3): a011858.

10. Kwok S, Fischer JL, Rogers JD. Benzocaine and lidocaine induced methemoglobinemia after bronchoscopy: a case report. J Med Case Rep. 2008; 2: 16.

11. Udeh C, Bittikofer J, Sum-Ping ST. Severe methemoglobinemia on exposure to benzocaine. J Clin Anesth. 2001; 13(2): 128-30.

12. Fan AM, Willhite CC, Book SA. Evaluation of the nitrate drinking water standard with reference to infant methemoglobinemia and potential reproductive toxicity. Regul Toxicol Pharmacol. 1987; 7(2): 135-48.

13. Sanchez-Echaniz J, Benito-Fernandez J, Mintegui-Raso S. Methemoglobinemia and consumption of vegetables in infants. Pediatrics. 2001; 107(5): 1024-8.

14. Greer RF, Shannon M; American Academy of Pediatrics Committee on Nutrition; American Academy of Pediatrics Committee on Environmental Health. Infant methemoglobinemia: the role of dietary nitrate in food and water. Pediatrics. 2005; 116(3): 784-6.

15. Казанец ЕГ. Метгемоглобинемии. Детская больница. 2009; 1: 38-42.

16. Nagai M, Yoneyama Y. Reduction of methemoglobins M Hyde Park, M Saskatoon and M Milwaukee by ferredoxin and ferredoxin-nicotinamide adenine dinucleotide phosphate reductase system. J Biol Chem. 1983; 258(23): 14379-84.

17. Arbane-Dahmane M, Rouabhi F, Hocine M, Benabadji M, Redad M, Blouquit Y, et al. Hemoglobin M Saskatoon (alpha 2 beta 263(E7) His->Tyr) in an Algerian family. Hemoglobin. 1985; 9(5): 509-11.


Review

For citations:


Usryugov A.Yu., Kazanets E.G., Zakharova G.S., Plyasunova S.A., Sadelov I.O. Methemoglobinemias in children (Review of literature and a clinical case report of a child with hemoglobin M Saskatoon). Pediatric Hematology/Oncology and Immunopathology. 2015;14(4):32-36. (In Russ.) https://doi.org/10.24287/1726-1708-2015-14-4-32-36

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ISSN 1726-1708 (Print)
ISSN 2414-9314 (Online)